25Sep 2021
How Alcohol Impacts the Risk of Blot Clots
4Platelets actually are not intact cells but disc-shaped cell fragments without nuclei that are released from giant precursor cells in the bone marrow called megakaryocytes. Spur cells are distorted RBC’s that are characterized by spikelike protrusions of their cell membrane (figure 2). These spurs are caused by the incorporation of excess amounts of cholesterol into the cell membrane, resulting in an increase of the cell’s surface area without a corresponding increase in cell volume. Modestly elevated membrane cholesterol levels result in a flattened RBC shape, whereas larger increments of cholesterol cause the membrane to be thrown up into spikes....
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